Investigation
- Age < 20 - disturbance is usually functional (hormonal disturbances) and resolves spontaneously
Active reproductive age group
- Exclude pregnancy and investigate for any organic causes
- Perimenopausal age - functional disorders are common; must rule out benign & malignant lesions
- Postmenopausal bleeding - rule out malignant lesions as it is very common
- Bimanual examination- including speculum examination should be done in all cases to rule out any local pathology and any growths
- Blood test: CBC, Platelet count, PTT, serum ferritin (in selective cases), TFT, RFT if needed, LFT, Prolactin, FSH, LH, etc, according to the age & condition of the patient
- USG (TVS) – to rule out organic lesions, Endometrial hyperplasia (Endometrial thickness> 12 mm)
- Hysteroscopy – Evaluation & biopsy of endometrial lesions can be done under direct vision
- Endometrial sampling
- Laparoscopy
- Diagnostic uterine curettage (D & C)