Acne vulgaris is a self-limited disease seen frequently in adolescents and primarily involves the sebaceous follicles. The hallmark of acne is comedones, which can develop further into inflammatory papules, pustules or even abscesses and nodules. As a sequelae to active lesions –pitted or hypertrophic scars will be formed
Symptoms typically begin in early puberty and cease spontaneously during the third decade of life
Types
Occurs predominantly on the face (99%), back (60%) and chest (15%). Infraorbital area is spared even in severe acne
Two type of lesions are seen : Non inflammatory (comedones) and inflammatory
Comedones are the pathognomonic lesions of Acne. They are conical, raised lesions with a broad base and plugged apex. Two types of comedones are seen – blackheads/ open comedones and white heads/ closed comedones
Inflammatory lesions include papules, pustules, and nodules or nodulocystic lesions. In the most severe variant, acne can present with cyst and abscesses
Some amount of scaring occurs in 90% acne .These could be hypertrophic scars, keloids, atrophic scars or ice pick scars
Nodular Acne (>5mmin diameter) commonly occurs on the back and neck
Acne conglobata : rare type of acne, which is highly inflammatory and presents with comedones, nodules, abscesses, and draining sinus tract. Healing occurs with severe scarring
Differential diagnosis
Rosacea : has facial flushing, typically pustules occurring over erythematous background
Perioral Eczema : lesions itch, skin is dry and there are no comedones
Acneiform drug eruptions : sudden onset, follicular monomorphous eruptions characterized by papules and pustules resembling acne
Investigation
Usually clinical diagnosis is made
Elevated serum androgens(>150 ng/ml) and DHEAS(>8000 ng/ml)
In patients with associated PCOD - LH: FSH ratio, serum progesterone, Prolactin, fasting insulin
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