Investigation
Blood :
- Serum calcium, phosphate, and parathyroid hormone (PTH) levels
- Alkaline phosphatase possibly elevated
Plain radiography
- Increased radiolucency is detectable in cortical bones
- Osteoporotic vertebral fracture
- Compression fracture
DEXA scan (dual-energy x-ray absorptiometry) :
- Osteoporosis: T-score ≤ -2.5 SD
- Osteopenia: T-score of -1 to -2.5 SD
- Osteoporosis is diagnosed if T-score ≤ -2.5 SD and/or a fragility fracture is present
Quantitative computed tomography (QCT) : measurement of true bone volume density