Ovarian insufficiency despite adequate gonadotrophin stimulation is termed as Primary ovarian insufficiency or premature ovarian follicle
When ovarian failure occurs before the age of 40, it is termed Premature Ovarian Failure. Women who experience ovarian failure prior to the age of 30 should have a genetic evaluation to ensure a normal karyotype
These women should also have an autoimmune workup because of possible autoimmune causes of ovarian failure
Types
Amenorrhoea
Hypomenorrhoea
Vaginal dryness due to hypoestrogenism
Night sweats, hot flashes, dyspareunia, and irritability
Increased gonadotropins
Infertility
Investigation
Serum FSH >40mIU/ml
Serum E2 level< 20 pg/ml
AMH (Antimullerian Hormone)
Ovarian biopsy
Treatments
HRT (Hormone Replacement Therapy)
In case of Autoimmune disorders, corticosteroids can be used
IVF with donor oocyte
Gonadectomy in the presence of Y chromosome to avoid malignancy
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