PREMATURE OVARIAN FAILURE

Description

  • Ovarian insufficiency despite adequate gonadotrophin stimulation is termed as Primary ovarian insufficiency or premature ovarian follicle 
  • When ovarian failure occurs before the age of 40, it is termed Premature Ovarian Failure. Women who experience ovarian failure prior to the age of 30 should have a genetic evaluation to ensure a normal karyotype
  • These women should also have an autoimmune workup because of possible autoimmune causes of ovarian failure

Etiology

  • Idiopathic
  • Turner’s syndrome
  • Gonadal dysgenesis
  • Trisomy 18 and 13
  • Autoantibodies against ovarian follicle
  • Polyglandular autoimmune syndrome
  • Mumps
  • Tuberculosis
  • Radiation
  • Chemotherapy
  • Galactosemia
  • 17 alpha-hydroxylase deficiency
  • Addison’s disease
  • Diabetes
  • FSH receptor absent/Defect (Savage syndrome)
  • Tobacco

Types

  • Amenorrhoea
  • Hypomenorrhoea
  • Vaginal dryness due to hypoestrogenism
  • Night sweats, hot flashes, dyspareunia, and irritability
  • Increased gonadotropins
  • Infertility

Investigation

  • Serum FSH >40mIU/ml
  • Serum E2 level< 20 pg/ml
  • AMH (Antimullerian Hormone)
  • Ovarian biopsy

Treatments

  • HRT (Hormone Replacement Therapy)
  • In case of Autoimmune disorders, corticosteroids can be used
  • IVF with donor oocyte
  • Gonadectomy in the presence of Y chromosome to avoid malignancy

 Ayurvedic Management

Internal Medicines 

  • Sukumaram Kashaya
  • Sathavaryadi Kashaya
  • Sukumaram Gritha
  • Thila Taila
  • Sathapushpa Taila
  • Lasuna Taila
  • Phalasarpis
  • Dhanwantharam Gutika

Procedures

  • Snehapana- Sukumara Gritha, Sathapushpa Taila, Phalasarpis
  • Vamana
  • Marsa Nasya- Ksheerabala Taila
  • Kashaya vasti
  • Uthara vasti 

Department

Female Infertility

Turn your phone into a full-featured Ayurveda clinic

Reference library, prescription studio, classical texts and everyday productivity tools — all in one app. Try Bhishak with a trial subscription; unlock the full experience once you’re in.

Get it on Google Play
Scroll