Types

• ALT is present in high concentrations in the liver and to a lesser extent in the kidney, heart, skeletal muscle, pancreas, spleen, and lungs. The function of ALT is to convert alanine, an amino acid found in proteins, into pyruvate, an important intermediate in cellular energy production. 
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Description

10 -40 U/L

When to get Tested

• When there is s/s of liver disease ( weakness , fatigue , loss of appetite, nausea, vomiting , Jaundice, Dark urine, light coloured stools, pruritus, swelling in the legs and ankles, tendency to bruise easily)
• People who are at an increased risk for liver diseases( who are exposed to Hepatitis viruses, heavy drinkers, h/o liver disease in family, taking drugs that can damage liver)

Elevated Level

• Hepatitis ( Viral , Auto immune )
• Use of hepato toxic drugs 
• Hepatic ischemia
• Cirrhosis 
• Hepatic tumour
• Reye’s syndrome
• Epstein Barr Virus(EBV)
• Myocardial Infarction 
• Myocarditis
• Renal Infarction 
• Pulmonary infarction
• Severe muscle trauma
•  Dermatomyositis
• Polymyositis 
• Seizure disorder
• Obesity
• Drugs - diphenylhydantoin, heparin therapy

Decreased Level