DENGUE

NS1 ANTIGENT

• Negative-<0.9 (index)
• Equivocal- 0.9-1.1(index) (repeat test after 1 week)
• Positive->1.1 (index)

DENGU IgM AND DENGUE IgG

• Negative : 1.64 IV or less
• Equivocal : 1.64-2.85 IV (repeat test after 10-14 days)
• Positive : >2.85 IV

• Dengue is an acute febrile infectious disease. It can be caused by all four serotypes (DEN-I,II,III,IV) of virus called dengue virus. The principal vector of the disease is a female mosquito called Aedes aegypti. Infected humans may serve as a source of infection to the mosquitoes.
• Dengue virus infection may be asymptomatic or may cause undifferentiated febrile illness, Dengue fever, or Dengue haemorrhagic fever including dengue shock syndrome. Infection with one dengue serotype gives lifelong immunity to that particular serotype, but there is no cross protection for the other serotypes. The clinical presentation depends on age, immune status of host, and the virus strain
• Dengue virus PCR, IgM, IgG and NS1 antigen tests is used to detect dengue fever
• IgM antibodies appear approximately 5 days after onset of symptoms and rise for the next 1-3 weeks
• IgM antibodies are detectable up to 6 months
• IgG are detectable at approximately 14 days after the onset of symptoms and are maintained.
• In secondary infection the dominant antibody is IgG.
• A high IgG level characteristic of secondary infection.
• In secondary infection the dominant antibody is IgG. The levels of IgM are lower. A high IgG level characteristic of secondary infection
• Anti dengue IgG appears shortly afterwards

• When there is s/s associated with Dengue following travel to an area where dengue is endemic or an outbreak is occurring  (Sudden high fever (104⁰- f), Severe head ache or pain behind the eyes, Joint, muscle and bone pain, Gum and nose bleeds, Easy bruising, Low WBC)