LIPOPROTEIN A

Description

  • < 30 mg/dl

Clinical significance

  • Lipoprotein (a) is predominantly a generic trait and the levels remain more or less constant after puberty . It is composed of 27 % protein , 65 % lipids and 8 % carbohydrates and thus has a composition similar to that of LDL but is generally present in much lower concentrations. The protein portions Lp(a) consists of Apo A & Apo B . It does not respond to typical strategies to lower LDL such as diet, exercise or lipid lowering Medications. 
  • Lp(a) is considered as a strong and independent cardio vascular risk factor including atherosclerosis and coronary heart disease. Levels greater than 30 mg/dl have been demonstrated to independently increase the risk of CHD by 6 fold
  • Lipoprotein (a) fat globule – one of the stickiest particles in the body is a ten fold greater risk factor for atherosclerosis than LDL, Since it promotes deposits of LDL in blood and plaque formation and promotes formation of clots in arteries.

When to get tested

  • When there is a family h/o heart disease at young age that is not explained by high LDL or low HDL Cholesterol. 
  • When there is an existing heart disease with healthy or mildly elevated lipid levels.

Elevated level

  • Atherosclerosis
  • Hypertension
  • Diabetes
  • Kidney disease
  • Inflammatory disease
  • Collagen disease

Decreased level

  • Liver disease

Profile

ALL TEST

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