RHEUMATOID FACTOR
Description
- < 20 IU/ml
Clinical significance
- RF is basically auto antibodies produced by inflammatory cells in the joints of 80 % of patients with Rheumatoid arthritis. RF may result in the formation of immune complexes that activate complement cascade and release leukocytic enzymes from neutrophils, causing tissue injury.
- RF forms part of the diagnostic and prognostic marker of rheumatoid arthritis. Results from RF determinations should however always be evaluated in conjunction with clinical and other lab finding because low RF levels do not necessarily demonstrate the absence of Rheumatoid arthritis and high RF concentration are not limited to only Rheumatic diseases
- Values may decrease during remission but rarely becomes negative.
When to get tested
Elevated level
- Infections (Bronchitis, kalaazar , leprosy, Sub acute bacterial endocarditis, syphilis , TB, viral infections )
- Liver Disease ( Biliary Obstruction , Cirrhosis , Fatty liver , Granuloma)
- Idiopathic pulmonary fibrosis
- Osteoarthritis
- Raynauds disease
- Sarcoidosis
- Sjogrens syndrome
- Rheumatoid Arthritis
- Leukemia
- SLE
Decreased level
Profile
ALL TEST
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