ANDROSTENEDIONE (A4)

Adult Males : 

• 0.57 – 2.65 ng/ml

Adult Females :

• 0.47 -2.68 ng/ml

• Androstenedione is a steroid produced in the adrenal gland and gonads. Androstenedione is an immediate precursor to both testosterone and estrone; subsequently both are converted to estradiol
• Androstenedione are high in foetal and neonatal serum, decreases during childhood and increases during puberty. The conversion of androstenedione to testosterone is a process activated by LH and thus controlled by the hypothalamus and the pituitary gland
• Measurement of A4 provides a useful marker of androgen biosynthesis and A4 levels may have all advantage over measurement of 17-OH Progesterone in monitoring treatment in Virilizing Congenital Adrenal Hyperplasia (CAH)

• Virilization
• Congenital adrenal hyperplasia
• Poly Cystic ovary Syndrome
• Ovarian stromal hyperthecosis
• 3 ß-OH steroid dehydrogenase deficiency
• Adrenal and ovarian Virilizing tumors
• Androgenetic alopecia

• Adrenal gland dysfunction
• Adrenal Insufficiency
• Ovarian or testicular failure