ANTIHEPATITIS E VIRUS (HEPATITIS E) IgM

OD Ratio

• Positive : ≤0.90
• Equivocal : 0.91-1.10
• Negative : ≥1.11

• HEV infection is also called as enterically transmitted non-A non-B hepatitis (ET-NANA), epidemic non-A non-B hepatitis, faecal –oral non A-non-B hepatitis, A-like non-A non-B hepatitis. The virus is transmitted primarily through faecal oral route, ingestion of contaminated water.
• This test is used to diagnose acute infection of HEV and in the differential diagnosis of hepatitis especially HAV

• When there is s/s of Hepatitis E ( Jaundice, Anorexia, hepatomegaly, abdominal pain and tenderness, nausea, vomiting and fever)
• Differential diagnosis of hepatitis especially HAV

False positive

• High titre of rheumatoid factor
• Hypergammaglobulinemia
• Paraprotinemia
• Passive antibody transfer
• Anti-idiotypes
• Anti-superoxide dismutase

False negative: -

• Early acute infection
• Immuno suppression
• Immuno incompetence
• Prolonged storage of blood sample