APOLIPOPROTEIN B

Description

  • Male : 55-140 mg/dl
  • Female : 55 -125 mg/dl

Clinical significance

  • Apolipoproteins combine with lipids to transport it through the blood stream. An enzyme called lipoprotein lipase removes triglyceride from VLDL to produce Intermediate lipoproteins and then LDL. 
  • Each VLDL particle contains one molecule of Apo B which is retained as VLDL loses triglycerides and shrinks to become the ore cholesterol rich LDL. 
  • Apo B is the major protein constituent of LDL and also constitutes about 40 % of VLDL. It is a convenient marker for assessing the cholesterol deposition capacity of the blood. It stabilises the cholesterol within the LDL complex.

When to get tested

  • When a person has a family history of heart disease and or high cholesterol and triglycerides (hyperlipidemia). 
  • To evaluate risk of developing CVD

Elevated level

  • High fat diet
  • Familial combined hyperlipidemia
  • Diabetes
  • Hypothyroidism
  • Pregnancy
  • Drugs such as Androgens , Beta blockers, Diuretics
  • Nephrotic syndrome

Decreased level

  • Abetalipoproteinemia or Bassen kornzweig syndrome
  • Hyperthyroidism
  • Malnutrition 
  • Reyes syndrome
  • Surgery
  • Cirrhosis

Profile

Cardiac

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