ANTI HBc TOTAL

OD Ratio

• Positive : ≥1.15
• Equivocal : 0.85-1.15
• Negative : <0.85

• Total anti hepatitis B core - ANTI HBc TOTAL (Total value of IgM +IgG)
• Detects both IgM and IgG antibodies to hepatitis B core antigen. It is used to help detect acute and chronic HBV infections; IgM antibody is the first antibody produced after infection with HBV; IgG antibody is produced in response to the core antigen later in the course of the infection and usually persists for life.
• Presence of anti-HBC antibody indicates an ongoing or previous HBV infection
• Anti HBC antibody detects persons who have been previously infected with HBV and can therefore serve as surrogate test for other infectious agents.
• Exclusion of Anti-HBC antibody positive donors reduces the incidence of post transfusion hepatitis

• When there is s/s associated with acute hepatitis such as Fatigue, Sudden nausea and vomiting, Abdominal pain or discomfort, especially on the upper right quadrant, Clay coloured stools, Loss of appetite, Low grade fever ,Dark urine , Joint pain, Jaundice ,Intense itching
• When there is s/s of chronic liver failure
• Above clinical features with history of unprotected sexual contact, Sharing of needles, Accidental needle pricks
• When new born shows signs of hepatitis

• Ongoing or previous HBV infection