GLOBULIN
Description
Adults : 2 - 3.5 g/dl
Alpha 1 - 0.1 – 0.3 g/dl
Alpha 2 : 0.6 -1 g/dl
Beta : 0.7 -1.1 g/dl
Clinical significance
- Globulins are group of proteins in blood. It amounts to 40 % proteins. Globulins are a varied group of proteins, some produced by the liver and some by the Immune system.
- It plays an important role in liver function, blood clotting and fighting infection. There are five main types of globulins, alpha 1, alpha 2, beta1, beta 2 and gamma
When to get tested
- When there is s/s like unexplained weight loss, Fatigue, Oedema.
- When there are symptoms of liver disease, kidney disease, or bone marrow disorder
Elevated level
- Alpha 1 Increased : Inflammatory stages , Pregnancy
- Alpha 2 Increased : Inflammatory states , nephritic syndrome , Oral contraceptive use, Steroid use , hyper thyroidism
- Beta Increased : Hyper lipidemia , Iron deficiency anaemia
- Gamma Increased : Polyclonal & Monoclonal Gammopathies
Decreased level
- Alpha 1 Decreased : Alpha 1 Antitrypsin deficiency
- Alpha 2 Decreased : Haemolysis , liver disease
- Beta Decreased: Hypo B Lipo proteinemia , malnutrition
- Gamma Decreased : Agammaglobulinemia , hypogamma globulinemia
Profile
Liver panel
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