HLAB 27
Description
- Result – Positive / Negative
Clinical significance
- Human Leukocyte Antigen B 27 is a major histo compatability complex class 1 molecule that is strongly associated with Ankylosing spondylitis. The test determines the presence or absence of HLAB 27 protein on the surface of a person’s white blood cells.
- There is a strong association between the presence of HLAB -27 antigen and an increased incidence of Ankylosing spondylitis as well as several other disorders such as Reiters syndrome, Psoriatic arthritis and arthropathies associated with inflammatory bowel disease . These disorders are collectively known as seronegative spondyloarthropathies
- HLAB 27 positive patient is more likely to exhibit spondyloarthropathies than a HLAB 27 negative patient.
When to get tested
- When a person has acute or chronic pain and inflammation in the spine , neck , chest , eyes and or joints and when there is a suspicion of Auto immune disorder
- When there is recurrent Uveitis
- When there is Suspicion of Ankylosing spondylitis.
Elevated level
- Ankylosing spondylitis
- Reactive Arthritis
- Other Auto immune disorders
Decreased level
Profile
Arthritis
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