SHBG is synthesized by liver cells and has a 7-day half life in circulation. In both sexes the SHBG concentration sharply increases just after birth and gradually declines until puberty. Male and female children have similar SHBG concentrations (ranging from 80 to 175 nmol/L) until the onset of puberty, when SHBG levels decrease more rapidl...
13 -71 nmol/L
Females ( Non Pregnant ) :
18 -114 nmol/L
When to get Tested
When the Testosterone levels do not seem to be consistent with clinical signs and symptoms, such as infertility, decreased sex drive, erectile dysfunction in men and infertility, irregular menstrual periods , and excess facial and body hair in women.
Administration of oral contraceptive
Phenytoin drug administration
Polycystic Ovary Syndrome
Modestly reduced in Hypothyroidism
Acromegaly, Cushing's disease, Hyperprolactinemia
Glucocorticoids and GH also have been observed to lower SHBG
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